(1987) suggested that protection of membranes from oxidative injury is an important function of phospholipase A2. Take a look at entry 1psh to see a trimeric form of cobra toxin. Diversity of Group Types, Regulation, and Function of Phospholipase A2 E A Dennis 1 Affiliations Expand Affiliation 1 Department of Chemistry-0601, University of California, San Diego, La Jolla 92093-0601. Synonym(s): lecithinase A , phosphatidase , phosphatidolipase Phospholipase A 2 is one of the most intensively studied membrane proteins which hydrolyzes phospholipids at the sn-2 position to form fatty acid and lysophospholipid products. Lp-PLA 2 is a calcium-independent phospholipase A2 enzyme that is associated with both low-density lipoprotein (LDL) and, to a lesser extent, high-density lipoprotein (HDL) in human plasma and serum 1 and is distinct from other such phospholipases such as cPLA 2 and sPLA 2. These are small proteins and the 3-D structures are known to high resolution for several species. Receptor for secretory phospholipase A2 (sPLA2). Structures of many types of phospholipase are available in the PDB archive, including some with trial inhibitors. Phospholipase A 1: structure, distribution and function – REVIEW Figure 3. phospholipase A2 activity Source: MGI "On the diversity of secreted phospholipases A2.

PS has been implicated in blood coagulation, phagocytosis and the activation of intracellular enzymes, such as PKC, and is a marker of apoptotic cells. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2.

Item in Clipboard Review. NX_P04054 - PLA2G1B - Phospholipase A2 - Function. Roles of PS-PLA 1, mPA-PLA 1α and mPA-PLA 1β in the production of lysophospholipid mediators. Phospholipase A2 is in fact a family of enzymes that are categorized by location and function. PMID: 8175726; Free article. PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes."


Also able to bind to snake PA2-like toxins. Some forms of phospholipase A2 associate into larger assemblies, although it is not known if these have a biological function.

Gene Structure Seilhamer et al. Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. (1986) found that the gene spans 4.9 kb and contains 3 introns. Van Kuijk et al. phospholipase A2: an enzyme that catalyzes the hydrolysis of a lecithin to a lysolecithin by removing the 2-acyl group; also acts on other phospholipids by removing a fatty acid from the 2-position; this enzyme has an important role in prostaglandin and leukotriene biosynthesis.

Phospholipase A2, which exists various isoforms, is an enzyme that is overactive during cerebral ischemia due to the influx of calcium into the cell.